منابع مشابه
5 Immunotoxicity
As evidenced by recent documents prepared by the Office of Technology Assessment (9) and the National Research Council in 1992 (8) focusing on immunotoxicology, there has been growing interest and concern within the scientific and public communities on the capacity of environmental agents to perturb normal immune processes. The types of effects that may occur are often agent-specific as well as...
متن کاملImmunotoxicity of Asbestos
The study of asbestos immunotoxicity is generally applied toward understanding the mechanisms that lead to its infamous outcomes, mesothelioma and asbestosis, rather than as an outcome itself. However, emerging evidence suggests that asbestos exposure has critical inflammatory and autoimmune effects. Although crystalline silica is broadly accepted as an exposure trigger for systemic autoimmune ...
متن کاملArsenic immunotoxicity: a review
Exposure to arsenic (As) is a global public health problem because of its association with various cancers and numerous other pathological effects, and millions of people worldwide are exposed to As on a regular basis. Increasing lines of evidence indicate that As may adversely affect the immune system, but its specific effects on immune function are poorly understood. Therefore, we conducted a...
متن کاملIn vivo assessment of immunotoxicity
The organs, tissues, and cells of the lymphoreticular system have received considerable attention as targets for chemicals causing adverse effects. A basic toxicological approach is described for assessing the risk of a chemical perturbing the immune system. CD-1 mice were exposed for 14 or 90 days to one of several chlorinated hydrocarbons: 1,2-dichloroethane, 1,2-dichloroethylene or 1,1,2-tri...
متن کاملNew approaches to immunotoxicity testing.
New approaches to immunotoxicity testing are reviewed and discussed. A method of activating T-cells in vivo is presented which circumvents artifacts dur to viability effects encountered with in vitro mitogen assays. The use of adoptive transfer approaches to combine the advantages of in vitro manipulation with in vivo function assays is discussed relative to natural killer cells. The need for a...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2008
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.131.215