Immunotoxic effect of low dose cisplatin in mice.
نویسندگان
چکیده
منابع مشابه
Immunotoxic Effect Dose Cisplatin in of Low Mice
The immunosuppressive effects of cisplatin at relatively low doses were investigated in CD-1 mice, Mice were injected intraperitonea]ly with 8, 40 and 20e yglkg cisplatin for 10 days, A decrease in bedy and thymus weights was observed at 200Ag!kg, Though there were no dose-related effects on the IgM antibody response to sheep erythrocytes, a statistically significant reduction of the contact hy...
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Cisplatin, a chemotherapeutic used for the treatment of solid cancers, has nephrotoxic side effects leading to acute kidney injury (AKI). Cisplatin cannot be given to patients that have comorbidities that predispose them to an increased risk for AKI. Even without these comorbidities, 30% of patients administered cisplatin will develop kidney injury, requiring the oncologist to withhold or reduc...
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Objective(s): The effects of low dose amphetamine on oxidative stress and rotenone-induced neurotoxicity and liver injury were examined in vivo in a mice model of Parkinson’s disease. Materials and Methods: Male mice were treated with rotenone (1.5 mg/kg, every other day for two weeks, subcutaneously). Mice received either the vehicle or...
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UNLABELLED The aims of this study were to investigate the anti-tumor effects of consecutive low-dose cisplatin (LD-CDDP) in comparison with single high-dose CDDP (HD-CDDP) in combination with caffeine. MATERIALS AND METHODS Human fibrosarcoma cells (HT-1080) were transplanted in BALB/C-nu mice. According to the administration of CDDP and caffeine, 5 groups were defined: HD-CDDP, LD-CDDP, HD-C...
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OBJECTIVES/HYPOTHESIS Cochlear preconditioning with low doses of kanamycin or noise can reduce susceptibility to noise- and ototoxic drug-induced hearing loss. The current study was undertaken to investigate whether a preconditioning regimen of low-dose cisplatin would alter susceptibility to ototoxicity induced by a single large dose of cisplatin. STUDY DESIGN In vivo study using an animal m...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1996
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.21.4_227