Immunotherapy of colorectal cancer: Challenges for therapeutic efficacy
نویسندگان
چکیده
منابع مشابه
Immunotherapy for Colorectal Cancer
The recent success of anti-PD1 drugs in metastatic colorectal cancer patients with mismatch repair deficiency generated overwhelming enthusiasm for immunotherapy in the disease. However, patients with mismatch repair deficient colorectal cancer represent only a small subset of the metastatic population. Current research focuses on advancing immunotherapy to earlier stages of the disease includi...
متن کاملImmunotherapy for colorectal cancer
Immunotherapy for colorectal cancer has been under investigation for many years. Many recent scientific advances contribute to the success of cancer immunotherapy, including our better understanding of anti-tumor immune response, tolerance and regulation, and the advent of newer therapies including agonist antibodies to the co-stimulatory molecules targeting T cells. Immunotherapy may represent...
متن کاملImmunotherapy for colorectal cancer.
BACKGROUND Advances in molecular biology have enabled specific antigens present on colorectal cells to be characterized, against which immune responses may be generated. This, in combination with our inability to significantly alter survival from this condition, has resurrected an interest in immunotherapy as a potential treatment option. DATA SOURCES The information contained in this review ...
متن کاملImmunotherapy of Colorectal Cancer.
It is known that the immune response, reflected by high T cell infiltrates in primary tumors and metastases, influences the clinical course of colorectal cancer (CRC). Therefore, immunotherapy concepts have been adapted from other tumor entities, which typically rely on the activation of T cells in the tumor microenvironment (e.g. blockade of the immune checkpoint molecules PD-1 and CTLA-4). Ho...
متن کاملImmunotherapy of colorectal cancer.
Over the last decade, there has been a rapid expansion in the field of tumour immunology. There is now convincing evidence that both the cellular and humoral arms of the immune system are capable of interacting with tumour cells. The most significant advances have been in our understanding of cellular responses and the complex events that lead to T-lymphocyte activation, as well as in the ident...
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ژورنال
عنوان ژورنال: Cancer Treatment Reviews
سال: 2019
ISSN: 0305-7372
DOI: 10.1016/j.ctrv.2019.04.003