Immunosuppression via Tenascin-C
نویسندگان
چکیده
منابع مشابه
Immunosuppression via Tenascin-C
Metastasis accounts for most of the prostate cancer-related deaths, and the presence of more than two metastatic lymph nodes at radical prostatectomy and extended pelvic lymph node (PLN) dissection is an independent predictor of prostate cancer specific mortality [1], thus suggesting that PLN invasion is an important event in the history of the disease. However, despite its clinical significanc...
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Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates, and molecular phylogeny indicates that it evolved before fibronectin. Tenascin-C has many extracellular binding partners, including matrix components, soluble factors and patho...
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Cell binding to extracellular matrix (ECM) components changes cytoskeletal organization by the activation of Rho family GTPases. Tenascin-C, a developmentally regulated matrix protein, modulates cellular responses to other matrix proteins, such as fibronectin (FN). Here, we report that tenascin-C markedly altered cell phenotype on a three-dimensional fibrin matrix containing FN, resulting in su...
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We read, with much interest, the recent Research Article by Järvinen et al. (Järvinen et al., 2003), in which the authors show that, after removing the cast from an immobilized rat hind leg, within 8 weeks tenascin-C (TN-C) expression is increased in tendon and the myotendinous junction, but there is no de novo appearance of TN-C in skeletal muscle connective tissue. The authors extensively cri...
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Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very restricted pattern of expression but an enormously diverse range of functions. Here, we discuss the importance of deciphering the expression pattern of, and effects mediated by, different forms of this molecule in order to fully understand tenascin-C biology. We focus on both post transcriptional and pos...
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2015
ISSN: 2331-4737
DOI: 10.18632/oncoscience.210