Immunophenotyping Investigation in Acute and Chronic Leukemias as a Gold Standard Test
نویسندگان
چکیده
Immunophenotyping of leukemias and other hematological neoplasms has become one the most relevant clinical applications flow cytometry which remains an indispensable tool for diagnosis, classification, staging as well hematologic malignancies monitoring. It can provide quantitative data on a number cell parameters large cells in region thousands per second making it powerful diagnostic tool. If immunophenotyping is more sensitive significantly, specific objective than morphological studying, latter gold standard criterion creating establishing blast percentage presentation post treatment together. Moreover, important that interpreters cytometric have phenotypes exact knowledge diverse normal populations, be best recognize deviations from are able to discuss potential significance knowing look findings.
منابع مشابه
Immunophenotyping of chronic lymphoid leukemias.
The 1983 article entitled “Chronic lymphocytic leukemia and other chronic lymphoid proliferations: surface marker phenotypes and clinical correlations,” which is reprinted in this issue of the Journal of Clinical Oncology, was one of the first reporting the use of monoclonal antibodies to expand the phenotypic characterization of chronic lymphoid leukemia, and one of the earliest to examine cli...
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Over a period of 3-1/2 years, 86 cases of acute leukemia were analyzed by immunohistochemical (IHC) means on ficoll separated cytospin preparations of peripheral blood and/or bone marrow samples. Antibodies included in the panel were specific against Tdt, HLA-DR, CD19/CD20/CD22, CALLA (CD10), CD2, CD11C as well as against Ig heavy chains. Of 86 cases analyzed, 48 cases were of ALL, (25 of commo...
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ژورنال
عنوان ژورنال: Journal of cancer research and cellular therapeutics
سال: 2022
ISSN: ['2640-1053']
DOI: https://doi.org/10.31579/2640-1053/106