Immunopathological Responses to the Bovine Mastitis Associated with Staphylococcus Species Infection

Bovine mastitis is a disease that concerns animals' welfare and increases the economic production losses. Bacterial agents such as Staphylococcus species are main causative agent of bovine mastitis. This bacterial expresses some inflammatory cytokines might enhance cell-mediated, which may promote pathogenesis The objective current study was to investigate innate immune response circulating levels pro-inflammatory anti-inflammatory cytokines. A total 10 mL milk specimens were collected randomly from 100 clinically mastitic cows, another 20 healthy cows considered control group for California Mastitis test. microbiological cultures performed. interleukins (ILs)that involved IL-4, IL-6, IL-10 detected using ELISA test evaluation pathophysiology. results this showed aureus detection in 31.2% 8.7% non-mastitic specimens; coagulase-negative 14.8% 18.7% specimens, respectively. IL-6 level shown significantly higher (P<0.05)in (194±12.8 pg/mL) compared (31±2.9 pg/mL). In conclusion, elevated expression cytokine with suggested be used potentially suitable biomarker early diagnosis