Immunomodulatory effects of high-dose and low-dose interferon ?2b in patients with high-risk resected melanoma
نویسندگان
چکیده
منابع مشابه
Health management program: factors influencing completion of therapy with high-dose interferon alfa-2b for high-risk melanoma
The goal of the 1-year observational, multicentre, open-label study reported here was to identify factors influencing adherence to high-dose interferon alfa-2b adjuvant therapy in patients at high risk of recurrence following surgical excision of malignant melanoma. The study was carried out in 23 tertiary-care centres across Canada.The 225 patients enrolled in the study all had malignant melan...
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BACKGROUND Pediatric patients with high-risk surgically resected melanoma are at risk for relapse, yet little is known about these young patients and how they tolerate high-dose interferon therapy. PROCEDURE We reviewed medical records of patients (< or =18 years) with high-risk melanoma referred to the University of Michigan Pediatric Hematology-Oncology service between January 1989 and July...
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High-dose interferon-alpha remains the first-line treatment in the adjuvant therapy of metastatic melanoma. More recently, high-dose pegylated interferon-alpha-2b has been approved by the US Food and Drug Administration. Actually, an adjuvant therapy alternative to high-dose interferon-alpha is represented by ipilimumab. Moreover, combination therapy of IFN-alpha or ipilimumab with tyrosine kin...
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ژورنال
عنوان ژورنال: Cancer
سال: 2002
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.10775