Immunomodulation and allogeneic blood transfusion

Deleterious consequences of allogeneic blood transfusion on postoperative infection: really a transfusion-related immunomodulation effect?

The purported deleterious effect of transfusion-related immunomodulation (TRIM) on postoperative infection and its prevention by leukoreduction of transfused blood are a matter of great controversy among transfusion medicine specialists. In a recent review on this issue,1 Vamvakas and Blajchman pointed out that current evidence supporting a beneficial effect of leukoreduction is inconclusive be...

Autologous transfusion and reducing allogeneic blood exposure.

Reducing the risk of allogeneic blood transfusion.

The restricted use of allogeneic blood transfusions has been accepted throughout the world as important in reducing risk, particularly of the transmission of infectious diseases. In orthopedic surgery reduced use of allogeneic transfusions has been shown to prevent both early and late postoperative infection. In this issue (page 310) Brian Feagan and colleagues describe transfusion practices an...

Allogeneic Red Blood Cell Transfusion Following the Total Hip Arthroplasty Triggers the Immunomodulatory Responses

Background and Aims: Total hip arthroplasty (THA) is a common orthopedic surgery. The main focus in the research of THA is immune responses in these patients following the blood transfusion.Therefore, in this study, we evaluated the immune modulation indexes such as T cell amplification, Tcell surface markers and also production of cytokines in the patients undergoing THA surgery following bloo...

Guidelines for policies on alternatives to allogeneic blood transfusion. 1. Predeposit autologous blood donation and transfusion.

This is the first of a series of newly prepared guidelines on alternatives to allogeneic blood transfusion. Further guidelines including the use of cell salvage and of pharmacological approaches to blood conservation will be published in due course. Decades of clinical application demonstrate that it is quite feasible to auto-transfuse blood that has been collected and stored for an interval of...