Immunological Response to Conventional COVID-19 Vaccines in a Cohort of Pakistani Healthy Recipients

نویسندگان

چکیده

Coronavirus disease 2019 mass vaccination has led to drastic reduction in hospitalizations and mortality. A number of case reports have emerged reporting coronavirus infection within days following vaccination. There is a need understand development immune antibodies the early post-vaccination period. prospective analysis immunoglobulin M G kinetics was conducted during first 28 d with either CanSino or Sinovac vaccines cohort 40 healthy volunteers. Serial blood samples were collected from volunteers right before dose vaccine (d 0) then on 4, 7, 14, 21, 24 post-vaccination. Using enzyme-linked immunosorbent assay, circulating anti-severe acute respiratory syndrome 2 receptor binding domain analyzed. Most recipients (31/40) did not develop any M. The remaining 9 showed typical curve appearing peaking 7 declining 21 beyond. Immunoglobulin response more 38/40 showing appearance which continued till end study This demonstrates that vaccine-induced M-based immunity cannot be relied few time needed better picture real situation.

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ژورنال

عنوان ژورنال: Indian Journal of Pharmaceutical Sciences

سال: 2023

ISSN: ['0250-474X', '1998-3743']

DOI: https://doi.org/10.36468/pharmaceutical-sciences.spl.611