منابع مشابه
Immunological Memory is Associative
This paper argues that immunological memory is in the same class of associative memories as Kanerva’s Sparse Distributed Memory, Albus’s Cerebellar Model Arithmetic Computer, and Marr’s Theory of the Cerebellar Cortex. This class of memories derives its associative and robust nature from a sparse sampling of a huge input space by recognition units (B and T cells in the immune system) and a dist...
متن کاملImmunological Memory in Mice
Plaque forming cells (PFC) of different immunoglobulin classes producing antibodies against sheep erythrocytes were separated according to their buoyant densities by means of equilibrium centrifugation in a stepwise BSA gradient. In the period of 7-10 days after immunization gammaM PFC are markedly enriched in fractions of low density and relatively depleted in fractions of high density. The di...
متن کاملImmunological Memory in Vitro
The immune responses to sheep erythrocytes of mouse spleen cell suspensions from immune and nonimmune donors were compared in vitro. In vivo immunity was only transiently reflected in vitro, and 8 wk after in vivo immunization the responses of cultures from immunized and nonimmunized mice were virtually identical. There appeared to be two mechanisms for an antibody response to sheep erythrocyte...
متن کاملImmunological memory in humans.
Specificity and memory are the defining characteristics of adaptive immune responses. Vaccines are predicated on the existence of immune memory, and the robustness of immune memory is a primary determinant of vaccine efficacy. How is immune memory maintained? Much progress has been made in this area over the past several years, and new human studies have added key insights into the longevity of...
متن کاملModelling Immunological Memory
Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first validate an experimental immunological simulator, developed by the authors, by simulating several theories of immunological memory with known results. We then ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunology & Cell Biology
سال: 2019
ISSN: 0818-9641,1440-1711
DOI: 10.1111/imcb.12280