Immunological function for TFEB
نویسندگان
چکیده
منابع مشابه
TFEB regulates lysosomal proteostasis.
Loss-of-function diseases are often caused by destabilizing mutations that lead to protein misfolding and degradation. Modulating the innate protein homeostasis (proteostasis) capacity may lead to rescue of native folding of the mutated variants, thereby ameliorating the disease phenotype. In lysosomal storage disorders (LSDs), a number of highly prevalent alleles have missense mutations that d...
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The transcription factor EB (TFEB) plays a pivotal role in the regulation of basic cellular processes, such as lysosomal biogenesis and autophagy. The subcellular localization and activity of TFEB are regulated by mechanistic target of rapamycin (mTOR)-mediated phosphorylation, which occurs at the lysosomal surface. Phosphorylated TFEB is retained in the cytoplasm, whereas dephosphorylated TFEB...
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Although many aspects of hepatic function have been known and studied for a number of years, little is known about the immunological function of the liver. Chronic liver disease is often accompanied by an absolute increase in serum gamma globulin concentration. All the major immunoglobulin classes may be involved, and the elevated globulin is due to increased synthesis rather than decreased met...
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Curcumin is a hydrophobic polyphenol derived from the herb Curcumalonga and its wide spectrum of pharmacological activities has been widely studied. It has been reported that Curcumin can induce autophagy through inhibition of the Akt-mTOR pathway. However, the effect of Curcumin on lysosome remains largely elusive. In this study, we first found that Curcumin treatment enhances autophagic flux ...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2014
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.2953