Immunologic Control of Mus musculus Papillomavirus Type 1

Immunologic Control of Mus musculus Papillomavirus Type 1

Persistent papillomas developed in ~10% of out-bred immune-competent SKH-1 mice following MusPV1 challenge of their tail, and in a similar fraction the papillomas were transient, suggesting potential as a model. However, papillomas only occurred in BALB/c or C57BL/6 mice depleted of T cells with anti-CD3 antibody, and they completely regressed within 8 weeks after depletion was stopped. Neither...

Spontaneous and Vaccine-Induced Clearance of Mus Musculus Papillomavirus 1 Infection

Mus musculus papillomavirus 1 (MmuPV1/MusPV1) induces persistent papillomas in immunodeficient mice but not in common laboratory strains. To facilitate the study of immune control, we sought an outbred and immunocompetent laboratory mouse strain in which persistent papillomas could be established. We found that challenge of SKH1 mice (Crl:SKH1-Hrhr) with MmuPV1 by scarification on their tail re...

Genetic control of a serum esterase component in Mus musculus.

Genetic control of erythrocytic esterase forms in Mus musculus.

TARCH or agar gel electrophoresis coupled with azo dye staining methods has permitted the detection of genetically determined variants of several forms of nonspecific carboxylic esterases in a protozoan (ALLEN 1961), maize ( SCHWARTZ 1960, 1964), Drosophila (WRIGHT 1963; WRIGHT and MACINTYRE 1963), and house flies (VELTHUIS and VAN ASPEREN 1963). In mammals, inherited electrophoretic variants o...

Expanding the genetic code of Mus musculus

Here we report the expansion of the genetic code of Mus musculus with various unnatural amino acids including Nɛ-acetyl-lysine. Stable integration of transgenes encoding an engineered Nɛ-acetyl-lysyl-tRNA synthetase (AcKRS)/tRNAPyl pair into the mouse genome enables site-specific incorporation of unnatural amino acids into a target protein in response to the amber codon. We demonstrate temporal...