Immunologic and Non-Immunologic Mechanisms Leading to Airway Remodeling in Asthma

Mechanisms of airway remodeling in asthma.

Asthma is a chronic inflammatory disease characterized by reversible airflow limitation and airway hyperresponsiveness. Persistent inflammation in airway tissues may lead to structural changes known as airway remodeling and consequently airway obstruction that is not fully reversible and progressive loss of lung function over time. It is generally accepted that airway remodeling is closely rela...

Immunologic and non-immunologic complications of a third kidney transplantation

BACKGROUND/AIMS Patients who undergo repeat kidney transplantations (KTs) are considered at high risk for experiencing immunologic and non-immunologic complications. In this study, we investigated the clinical outcomes, including medical and surgical complications, of patients who underwent a third KT at our center. METHODS Between March 1969 and December 2012, a total of 2,110 KTs were perfo...

[Non-immunologic hydrops fetalis].

[Myocardial remodeling and immunologic activation in patients with heart failure].

INTRODUCTION AND OBJECTIVES Immune response-mediated regulation of myocardial collagen remains poorly understood. Our objective was to investigate the relationship between ventricular remodeling and immunologic activation in patients with heart failure (HF) by comparing dilated and ischemic cardiomyopathy. METHODS We studied 94 patients with HF and dilated cardiomyopathy (n=46) or ischemic ca...

Airway remodeling in asthma: therapeutic implications of mechanisms.

Asthma is currently recognized as a chronic inflammatory disorder of the airways that leads to tissue injury and subsequent structural changes collectively called airway remodeling. Transgenic modeling of inflammatory mediators allows for the discovery of unexpected effects, dissection of downstream signaling events, and clues to future therapies.