Immunohistochemical Study of Helix Pomatia Agglutinin Binding on Esophageal Cancers
نویسندگان
چکیده
منابع مشابه
Lectin histochemical study of cell surface glycoconjugate in gastric carcinoma using helix pomatia agglutinin.
Altered glycosylation of proteins in cancer cells is one of the main processes responsible for anaplasia, invasion and metastatic potential of neoplastic cells. Lectins are nonimmunogenetic compounds which specifically detect certain terminal sugars of glycoconjugates. The aim of the present study was to identify the N-acetylgalactosamine (GalNac) containing glycoconjugates in cancer cells in a...
متن کاملlectin histochemical study of cell surface glycoconjugate in gastric carcinoma using helix pomatia agglutinin
altered glycosylation of proteins in cancer cells is one of the main processes responsible for anaplasia, invasion and metastatic potential of neoplastic cells. lectins are nonimmunogenetic compounds which specifically detect certain terminal sugars of glycoconjugates. the aim of the present study was to identify the n-acetylgalactosamine (galnac) containing glycoconjugates in cancer cells in a...
متن کاملIdentification of O-Linked Glycoproteins Binding to the Lectin Helix pomatia Agglutinin as Markers of Metastatic Colorectal Cancer
BACKGROUND Protein glycosylation is an important post-translational modification shown to be altered in all tumour types studied to date. Mucin glycoproteins have been established as important carriers of O-linked glycans but other glycoproteins exhibiting altered glycosylation repertoires have yet to be identified but offer potential as biomarkers for metastatic cancer. METHODOLOGY In this s...
متن کاملEsophageal Cancers: A Clinicopathologic and Immunohistochemical Study of 223 Cases
The author reviewed 950 cases of consecutive esophageal biopsies in the last 15 years in out pathology laboratory of our hospital. There were 223 malignant lesions (23.5%). The number and frequency (percentages) were as follows: 54 mild dysplasia (5.7%), 30 moderate dyplasia (3.2%), 32 severe dysplasia (3.4%), 13 carcinoma in situ (1.4%), 71 squamous cell carcinoma (7.5%), 7 primary adenocarcin...
متن کاملBiochemical and structural analysis of Helix pomatia agglutinin. A hexameric lectin with a novel fold.
Helix pomatia agglutinin (HPA) is a N-acetylgalactosamine (GalNAc) binding lectin found in the albumen gland of the roman snail. As a constituent of perivitelline fluid, HPA protects fertilized eggs from bacteria and is part of the innate immunity system of the snail. The peptide sequence deduced from gene cloning demonstrates that HPA belongs to a family of carbohydrate-binding proteins recent...
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ژورنال
عنوان ژورنال: The Japanese Journal of Gastroenterological Surgery
سال: 1991
ISSN: 0386-9768,1348-9372
DOI: 10.5833/jjgs.24.1333