Immunohistochemical expression of p16INK4a in premalignant lesions and malignant tumours of cervix

Background: Cervical carcinoma is the third most common cancer in women worldwide and firth cause of related deaths. Human Papilloma virus, cervical cancer, causes functional inactivation pRb, resulting overexpression p16INK4a. The p16INK4a correlates well with degree dysplasia neoplasia. present study done to determine IHC expression so that it may be used as a biomarker for HPV play role prevention, diagnosis prognosis neoplasm. Methods: was conducted on 60 formalin-fixed, paraffin-embedded specimens neoplasms, which comprised 47 cases squamous cell followed by 8 adenocarcinoma, 3 HSIL 2 LSIL. These were then subjected Cytoplasmic nuclear positivity noted. Results: Overall 95% positive expression, 100% 98% carcinoma, 0% LSIL p16 expression. Conclusions: showed statistical correlation immunoreactivity histological type clinically significant (p value <0.0001). In our study, immunohistochemical increased increasing presence carcinoma.