Immunoglobulin heavy chain locus of the rat: striking homology to mouse antibody genes.
نویسندگان
چکیده
منابع مشابه
Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes.
We report the nucleotide sequence of a gene encoding a human immunoglobulin C gamma 2 region. Comparison with the previously determined C gamma 4 sequence reveals that these two genes share extensive (approximately 95%) homology in the three CH domain exons and adjacent noncoding regions. In contrast, hinge exons have diverged to a much greater degree, implying that natural selection has favore...
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Immunoglobulin heavy chain genes were found in wild mice (Mus musculus) that could best be explained as recombinants of immunoglobulin genotypes. In wild mice from Kitty Hawk, N. C., two new heavy chain linkage groups, G(3,5,7,8)H(9,11)F(f)A(-) and G(3,5,8)H(9,11)F(f)A(-), were found, each of which genetically controls both the 3 and 5 distinct immunoglobulin determinants. In inbred strains the...
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The intronic Emicro enhancer has been implicated in IgH locus transcription, VDJ recombination, class switch recombination, and somatic hypermutation. How Emicro controls these diverse mechanisms is still largely unclear, but transcriptional enhancer activity is thought to play a central role. In this study we compare the phenotype of mice lacking the Emicro element (DeltaEmicro) with that of m...
متن کاملStructural studies of a heavy chain from a mouse immunoglobulin M with antibody activity.
The molecular weight of the heavy chain (p) of the immunoglobulin M isolated from mouse myeloma tumor MOPC 104E is 73,000 as determined by gel filtration. Of the heavy chain, 13.3 % or 9,700 g/73,000 g of protein is carbohydrate, yielding a carbohydrate-free molecular weight of 63,000. By amino acid analysis the heavy chain consists of 549 residues, with molecular weight 61,000. The NH2-termina...
متن کاملOrganization of immunoglobulin heavy chain genes and allelic deletion model.
We have assessed the number of times the gene sequence encoding constant regions of mouse immunoglobulin heavy chains gamma1, gamma2a, and gamma3 are represented in the mouse genome by hybridization kinetic analysis. All three genes are present at one copy each per haploid genome in normal tissues and myelomas producing IgM or IgG3. IgG1-producing myelomas, however, contain 1 copy each of the g...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1986
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.83.16.6075