IMMUNOGLOBULIN GENE REARRANGEMENTS IN HUMAN MULTIPLE MYELOMA
نویسندگان
چکیده
منابع مشابه
Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma.
The ability to rearrange the germ-line DNA to generate antibody diversity is an essential prerequisite for the production of a functional repertoire. While this is essential to prevent infections, it also represents the "Achilles heel" of the B-cell lineage, occasionally leading to malignant transformation of these cells by translocation of protooncogenes into the immunoglobulin (Ig) loci. Howe...
متن کاملMethylation Status of SMG1 Gene Promoter in Multiple Myeloma
Background: Epigenetic modifications, such as methylation can occur in multiple myeloma. SMG1is an important gene involved in cell growth which defect in methylation of its promoter leads to reduction of cell apoptosis and uncontrolled proliferation. In this study, we identified the methylation status of the SMG1 gene promoter in patients with multiple myeloma. Methods: Methylation status of S...
متن کاملMolecular characteristics and gene segment usage in IGH gene rearrangements in multiple myeloma.
BACKGROUND AND OBJECTIVES Analysis of IgH rearrangements in B-cell malignancies has provided clinical researchers with a wide range of information during the last few years. However, only a few studies have contributed to the characterization of these features in multiple myeloma (MM), and they have been focused on the analysis of the expressed IgH allele only. Comparison between the expressed ...
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Bone marrow cells of 82 patients with multiple myeloma were subjected to flow cytometric analysis of DNA and cytoplasmic immunoglobulin (CIg) content using propidium iodide and direct immunofluorescence assays. Except for two patients with nonsecretory myeloma, there was conformity in the immunoglobulin type derived from immunoelectrophoresis and plasma cell CIg staining. One patient with nonse...
متن کاملRegulation of immunoglobulin heavy-chain gene rearrangements.
Regulated assembly of antigen receptor gene segments to produce functional genes is a hallmark of B- and T-lymphocyte development. The immunoglobulin heavy-chain (IgH) and T-cell receptor beta-chain genes rearrange first in B and T lineages, respectively. Both loci require two recombination events to assemble functional genes; D-to-J recombination occurs first followed by V-to-DJ recombination....
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 1989
ISSN: 0007-1048,1365-2141
DOI: 10.1111/j.1365-2141.1989.tb07769.x