Immunofluorescent Localization of Antihemophilic Factor Antigen and Fibrinogen in Human Renal Diseases
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چکیده
منابع مشابه
Antihemophilic factor antigen. Localization in endothelial cells by immunofluorescent microscopy.
The tissue localization of antihemophilic factor (AHF, Factor VIII) has been determined by immunofluorescent studies using monospecific rabbit antibody to human AHF. Specific staining demonstrating AHF antigens has been identified in endothelial cells of a wide range of human tissues. The staining pattern was observed in endothelial cells of arteries, capillaries, and veins as well as the cells...
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Gamma globulin and complement have been demonstrated in renal glomeruli of patients with glomerulonephritis (1-10). Certain problems, which are the subject of the present investigation, remain to be elucidated: 1) the type of immunoglobulin (y2, 71m, or yiA) present in the renal lesion and its relation to complement localization; and 2) the significance of fibrinogen localization. Kidneys from ...
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Antihemophilic factor (AHF, Factor VIII) antigen has been demonstrated in cultured human endothelial cells by immunofluorescence studies using monospecific rabbit antibody to human AHF. Control studies with cultured human smooth muscle cells and human fibroblasts were negative. By radioimmunoassay it was demonstrated that cultured human endothelial cells contain AHF antigen which is released in...
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The heterogeneity of human circulating anticoagulants against antihemophilic factor (AHF, factor VIII) observed in seven patients, both with and without classic hemophilia, was investigated by neutralization of their activity with antiserums directed to whole IgG and to lambda and kappa light chains. All seven anticoagulants were immunoglobulins. Six appeared to contain both kinds of light chai...
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Antihemophilic Factor/von Willebrand Factor Complex (Human), Dried, Pasteurized, Humate-P is a stable, purified, sterile, lyophilized concentrate of Antihemophilic Factor (Human) and von Willebrand Factor (VWF) (Human) to be administered by the intravenous route in the treatment of patients with classical hemophilia (hemophilia A) and von Willebrand disease (VWD) (see CLINICAL PHARMACOLOGY). Hu...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1974
ISSN: 0021-9738
DOI: 10.1172/jci107686