Immunization of cattle with recombinant Babesia bovis merozoite surface antigen-1
نویسندگان
چکیده
منابع مشابه
Babesia bovis merozoite surface antigen-1. Immunization of cattle with recombinant
Babesia bovis merozoite surface antigen-1.
متن کاملInsilico Validation of Babesia Bovis Merozoite Surface Antigen-1, Merozoite Surface Antigen-2b and Merozoite Surface Antigen-2c Proteins for Vaccine and Drug Development
The Babesia bovis MSA-1, MSA-2b and MSA-2c are members of the variable merozoite surface antigen (VMSA) family, they are encoded surface proteins that are proposed to mediate the initial attachment of the merozoite to the host erythrocyte so this protein are targeted for vaccine and drug design. So the aim of this study is to give an outlook for MSA-1, MSA-2b and MSA-2c proteins using bioinform...
متن کاملGenotypic diversity of merozoite surface antigen 1 of Babesia bovis within an endemic population
Multiple genetically distinct strains of a pathogen circulate and compete for dominance within populations of animal reservoir hosts. Understanding the basis for genotypic strain structure is critical for predicting how pathogens respond to selective pressures and how shifts in pathogen population structure can lead to disease outbreaks. Evidence from related Apicomplexans such as Plasmodium, T...
متن کاملThe Babesia bovis merozoite surface antigen 1 hypervariable region induces surface-reactive antibodies that block merozoite invasion.
A hypervariable region (HVR) previously identified in the carboxy-terminal one-third of the Babesia bovis variable merozoite surface antigen family was more extensively analyzed in merozoite surface antigen 1 (MSA-1) from 16 strains and isolates. The MSA-1 HVR is proline rich and contains three semiconserved motifs nearly identical to those described for the related family member MSA-2. Two MSA...
متن کاملStrain variation of Babesia bovis merozoite surface-exposed epitopes.
Babesia bovis merozoites are exposed to antibodies during the extraerythrocytic phase, and surface polypeptides bearing exposed epitopes are possible immunogens. Monoclonal antibodies reactive with the merozoite surface bind either immunodominant epitopes expressed diffusely on the merozoite surface or, alternatively, epitopes expressed in a polar pattern. Epitopes expressed diffusely on the im...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1995
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.63.1.349-352.1995