Immune myopathies with perimysial pathology

Immune myopathies with perimysial pathology

Objective Immune myopathies with perimysial pathology (IMPP) have a combination of damage to perimysial connective tissue and muscle fiber necrosis, more prominent near the perimysium. We studied the clinical and laboratory correlates of patients with pathologically defined IMPP. Methods This is a retrospective chart and pathology review of 57 consecutive patients with IMPP myopathology and, fo...

Immune myopathies with perimysial pathology: Clinical and laboratory features.

Objective Immune myopathies with perimysial pathology (IMPP) have a combination of damage to perimysial connective tissue and muscle fiber necrosis, more prominent near the perimysium. We studied the clinical and laboratory correlates of patients with pathologically defined IMPP. Methods This is a retrospective chart and pathology review of 57 consecutive patients with IMPP myopathology and, ...

Pathology of Adult and Paediatric Mitochondrial Myopathies

Pathology and Biology of Inflammatory Myopathies

T he idiopathic inflammatory myopathies (IIMs) are an important heterogenous group of potentially treatable acquired disorders. On the basis of clinical, histological and immuno-pathogenic features, three distinct subsets are recognised: dermatomyositis (DM), polymyositis (PM) and sporadic inclusion-body myositis (IBM). An accurate diagnosis is important, given the potential toxicity associated...

High aldolase with normal creatine kinase in serum predicts a myopathy with perimysial pathology.

OBJECTIVE To study the clinical and pathological correlations of neuromuscular patients with a high aldolase and normal creatine kinase (CK) in serum at presentation or during a symptomatic exacerbation. METHODS Records and muscle biopsies were retrospectively reviewed in a consecutive series of 12 patients. Pathological results were compared to 75 abnormal muscle biopsies associated with acq...