منابع مشابه
Huntingtin and the molecular pathogenesis of Huntingtons disease
Huntington’s disease (HD) is a late-onset neurodegenerative disorder that is caused by a CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin (htt). The normal function of htt, and the molecular mechanisms that contribute to the disease pathogenesis, are in the process of being elucidated. In this review...
متن کاملPractice, progress and future directions for physical therapies in Huntingtons disease.
Physical therapies and exercise may have potential as a disease modifying agent in Huntington's disease (HD) and in recent years, there have been several small scale feasibility studies that have shown benefit as a result of physical interventions. When evaluating complex physical interventions, a phased approach using mixed methodology designs that report specific intervention components, adhe...
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Endothelial Dysfunction The endothelium constitutes the largest organ system in the body. “Endothelial function” refers to a multitude of physiological functions of the vascular endothelium that are achieved via secretion of diverse bioactive substances. This renders the endothelium an active participant in healthy homeostasis of the vascular wall that includes normal vasomotion, inhibition of ...
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ژورنال
عنوان ژورنال: Expert Review of Neurotherapeutics
سال: 2008
ISSN: 1473-7175,1744-8360
DOI: 10.1586/14737175.8.12.1779