Immune deficiency diseases.

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Immune deficiency diseases.

Paediatricians have long been deeply concerned with problems of infection. The sharp decrease in childhood mortality in recent decades in highly developed countries is mainly due to progress in preventing and treating infection: for example, in Switzerland in 1973 there were about 88 000 births and only 16 deaths due to infection in children aged between 2 and 4 years in contrast to 76 killed b...

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Pulmonary manifestations of immune deficiency diseases.

The defense of the respiratory system against infection involves a complex interplay of the humoral immune system and the cellular immune system with complement and phagocytic cells. The respiratory tract is an important portal of entry for infection, and it is therefore not surprising that many immune deficiencies present initially with a respiratory infection. Thus, pediatric pulmonologists m...

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Complement: Deficiency Diseases

Individuals with genetically determined complement deficiencies have a variety of clinical presentations. Most patients present with an increased susceptibility to infection, otherswith a variety of rheumatic diseases, still others with angio-oedema, and in rare instances, patients may even be asymptomatic. The elucidation of the pathophysiological basis for the different clinical presentations...

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The NAD Deficiency Diseases

Vitamin B3 occurs in two forms, nicotinamide and nicotinic acid. They were first isolated from liver in 1937 by Conrad El-vehjem and shown to be what was then called the PP factor or pellagra preventative factor. The name was later changed to vitamin B3, commonly called niacin for the nicotinic acid form and niacinamide for the amide form. Soon after, a synopsis of the early research on the com...

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Host Immune Deficiency in Immune Complex Nephritis1

Evidence is reviewed that indicates that an immune deficiency state may underlie patients with immune complex nephritis. Studies in several laboratories provide data that show defective immune function in patients with nephritis at the following loci: defective immunoglobulin production, impaired monocyte Fc and C3b receptor function, diminished complement biosynthesis, and decreased mesangial ...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1975

ISSN: 0021-9746

DOI: 10.1136/jcp.s1-6.1.83