Immune cells as tumor drug delivery vehicles

Polymeric micelles as drug delivery vehicles

Nerve guidance channels as drug delivery vehicles.

Nerve guidance channels (NGCs) have been shown to facilitate regeneration after transection injury to the peripheral nerve or spinal cord. Various therapeutic molecules, including neurotrophic factors, have improved regeneration and functional recovery after injury when combined with NGCs; however, their impact has not been maximized partly due to the lack of an appropriate drug delivery system...

Mesenchymal Stem Cells as Gene Delivery Vehicles

Mesenchymal stem cells (MSCs) possess a battery of unique properties which make them ideally suited not only for cellular therapies/regenerative medicine, but also as vehicles for gene delivery in a wide array of clinical settings. These include: 1) widespread distribution throughout the body; 2) ease of isolation and ability to be extensively expanded in culture without loss of potential; 3) t...

Engineering endogenous inflammatory cells as delivery vehicles.

Leukocytes are central in directing host inflammatory and immune processes; therefore, leukocyte response to biomaterials is extremely important. Although several leukocyte-derived molecules are used clinically, the long-term efficacy of treatments involving the systemic administration of these bioactive agents has yet to be demonstrated. Hence, the localized delivery of selected cytokines and ...

Density Functional Theory Calculations of Functionalized Carbon Nanotubes with Metformin as Vehicles for Drug Delivery

Drug delivery by nanomaterials is an active emergent research area and CNTs draws considerable potential application owing to its unique quasi one-dimensional structure and electronic properties. Single walled carbon nanotubes and carbon fullerenes can be used in drug delivery due to their mechanical and chemical stability. The past few years, increasing attention by several reputed groups has ...