Immiscibility in phosphatidylcholine-cholesterol mixtures
نویسندگان
چکیده
منابع مشابه
Observation of Fluid–Fluid Immiscibility in Ternary Mixtures of DPPC, DOPC and Cholesterol
As discussed chapter 1, cholesterol–rich domains in biomembranes, called rafts, are believed to be involved in many cellular functions [1, 2, 3, 4, 5]. Biochemical studies on the insoluble membrane fraction obtained from detergent extraction of plasma membranes show that it mainly consists of saturated lipids, such as sphingomyelin and cholesterol. The detergent insoluble fraction, known as det...
متن کاملCholesterol-induced fluid-phase immiscibility in membranes.
The fluid-phase behavior of binary mixtures of cholesterol with phosphatidylcholines is investigated using magnetic resonance methods. Phospholipid biradicals provide the electron spin resonance spectroscopic resolution of two immiscible fluid phases in the dipalmitoylphosphatidylcholine-cholesterol system. Isotropic chemical shifts of the phospholipid carbonyl carbons in binary mixtures with c...
متن کاملBilayer polarity and its thermal dependency in the l(o) and l(d) phases of binary phosphatidylcholine/cholesterol mixtures.
Diverse variations in membrane properties are observed in binary phosphatidylcholine/cholesterol mixtures. These mixtures are nonideal, displaying single or phase coexistence, depending on chemical composition and other thermodynamic parameters. When compared with pure phospholipid bilayers, there are changes in water permeability, bilayer thickness and thermomechanical properties, molecular pa...
متن کاملCholesterol Organization in Phosphatidylcholine Liposomes: A Surface Plasmon Resonance Study
Models for the organization of sterols into regular arrays within phospholipid bilayers have been proposed previously. The existence of such arrays in real systems has been supported by the fact that concentration-dependent sterol properties show discontinuities at the cholesterol mole fractions corresponding to regular lattice arrangements. Experimental results presented here are based on a su...
متن کاملUnit cell volume and liquid-phase immiscibility in oleate-stearate lipid mixtures.
The structural basis of immiscibility of stearic acid (SA) in two unsaturated lipids at room temperature was examined. A 5% SA mixture in octadec-9-enoic acid (OA) is cloudy; a 5% SA solution in the methyl ester of OA (MeOA) is fully miscible. At 10% SA in MeOA, a clear and immiscible phase formed. The composition of this immiscible phase however was not 10% SA, but 25% SA. Adding additional SA...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1976
ISSN: 0014-5793
DOI: 10.1016/0014-5793(76)80094-4