Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents
نویسندگان
چکیده
منابع مشابه
Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents
On the basis of the initial success of optimization of a novel series of imidazolopiperazines, a second generation of compounds involving changes in the core piperazine ring was synthesized to improve antimalarial properties. These changes were carried out to further improve the potency and metabolic stability of the compounds by leveraging the outcome of a set of in vitro metabolic identificat...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2012
ISSN: 0022-2623,1520-4804
DOI: 10.1021/jm300041e