Imbalances of chemokines, chemokine receptors and cytokines in Hodgkin lymphoma: Classical Hodgkin lymphomavs. Hodgkin-like ATLL
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چکیده
منابع مشابه
Hodgkin Lymphoma and Anaplastic Variants of Non-Hodgkin Lymphoma
Background and Objectives: Classic Hodgkin lymphoma (CHL), anaplastic large cell lymphoma (ALCL) and some cases of diffuse large B cell lymphoma (DLBCL) have overlapping morphologic features. Since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic impact of immunophenotyping to discriminate between them. Materials and Methods:...
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PURPOSE Although the International Prognostic Score (IPS) is the gold standard for risk-stratifying patients with classical Hodgkin lymphoma (cHL), these criteria do not accurately predict outcome. As cytokines are critically involved in driving cHL, we tested whether pretreatment serum cytokine levels could provide additional prognostic information. EXPERIMENTAL DESIGN Thirty cytokines were ...
متن کاملThe role of cytokines in classical Hodgkin lymphoma.
The clinical and pathologic features of classical Hodgkin lymphoma (cHL) reflect an abnormal immune response that is thought to be due to the elaboration of a variety of cytokines by the malignant Reed-Sternberg (RS) cells or surrounding tissues. The majority of cHL cases are characterized by expression of tumor necrosis factor receptor (TNFR) family members and their ligands, as well as an unb...
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We read with interest the study by Marri and colleagues (1) suggesting that in patients with classical Hodgkin lymphoma (cHL), the pretreatment cytokine profile, particularly serum levels of IL6 and IL2R, may be used to identify those at high risk for early-disease relapse. The authors further suggest that targeting the cross-talk between Hodgkin–Reed/Sternberg cells and reactive stromal cells ...
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Hodgkin lymphoma (HL) accounts for about 10% of all childhood cancers. Five-year survival rates with modern therapies are now approaching >90-95% as a consequence of its significant sensitivity to both chemotherapy and radiation. The current challenge is to determine how much therapy is needed to improve survival and how to adapt treatment to the patient to prevent these long term toxicities. T...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2003
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.11301