Imbalance of the antioxidative system by plumbagin and Plumbago indica L. extract induces hepatotoxicity in mice
نویسندگان
چکیده
منابع مشابه
Imbalance of the antioxidative system by plumbagin and Plumbago indica L. extract induces hepatotoxicity in mice.
BACKGROUND/AIM Plumbago indica (PI) L. and its active constituent, plumbagin, has been traditionally claimed for several pharmacological activities; however, there is little information regarding their toxicity. The present study aims to examine the effects of plumbagin and PI extract (PI) on hepatic histomorphology and antioxidative system in mice. MATERIALS AND METHODS Adult male intelligen...
متن کاملA Reverse Phase HPLC-UV and HPTLC Methods for Determination of Plumbagin in Plumbago indica and Plumbago zeylanica
A reverse phase HPLC method with UV detection has been developed and validated in order to quantify plumbagin, the bioactive marker of the roots of P. indica and P. zeylanica. A quantitative HPTLC method was also developed using hexane: ethyl acetate (8:2) as the mobile phase. The plumbagin content in the roots were determined using both the methods. P. indica was found to contain significantly...
متن کاملPlumbagin quantification in roots of Plumbago scandens L. obtained by different extraction techniques.
The Plumbago genus belongs to the Plumbaginaceae family and it is known due to its variety of biological uses, most of them attributed to the presence of naphthoquinones. Plumbagin is a naturally occurring naphthoquinone that can be obtained from roots of Plumbago scandens L. In order to find out the better technique for plumbagin extraction, were applied: static maceration, dynamic maceration,...
متن کاملPlumbago indica pdf
Includes 3 species, namely Plumbago indica P. Plumbago indica Plumbaginaceae is a perennial herb, commonly cultivated. Research project indicated that P. indica roots are indeed rich in. Nisha Sharma and Purshotam Kaushik. The present review deals with chemical compounds, medicinal.The aerial part of Plumbago indica L. family: Plumbaginaceae was studied to fix. Screening process of Plumbago ind...
متن کاملPlumbagin production by root cultures of Plumbago rosea
∗ Corresponding author Root cultures of Plumbago rosea Linn. were established from young leaf explants on solid Gamborg's B5 (B5) medium supplemented with the combination of αnaphthalene acetic acid (NAA) and kinetin in the concentration ranges of 0.5-2.0 mg/l and 0.1-0.5 mg/l, respectively. The production of plumbagin, determined by TLC-densitometry was higher [0.016 ± 0.0030% dry weight (DW)]...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Intercultural Ethnopharmacology
سال: 2016
ISSN: 2146-8397
DOI: 10.5455/jice.20160301094913