Imaging androgen receptor function during flutamide treatment in the LAPC9 xenograft model
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چکیده
منابع مشابه
Imaging androgen receptor function during flutamide treatment in the LAPC9 xenograft model.
The current understanding of the response of androgen receptor to pharmacologic inhibitors in prostate cancer is derived primarily from serum prostate-specific antigen (PSA) levels. In this study, we test whether a novel androgen receptor-specific molecular imaging system is able to detect the action of the antiandrogen flutamide on androgen receptor function in xenograft models of prostate can...
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Maternal testosterone has been indicated to affect sex ratio of offspring. The present study was conducted to elucidate the role of androgen receptor in this regard by blockade of androgen receptor using flutamide in female mice. Mice were randomly assigned to two experimental groups. Mice in the control (n = 20) and treatment (n = 20) groups received 8 IU equine chorionic gonadotropin (eCG) fo...
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Prostate cancer (PCa) is the most commonly diagnosed cancer and the second leading cause of cancer-related deaths among North American men (Jemal et al., 2003; Greenlee et al., 2006). The patients are sensitive to initial anti-androgen therapies. After a medium time of 18 months to 3 years, they will switch to the stage of an androgenindependent prostate cancer (AI-PCa), which is rapidly fatal....
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2005
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-05-0197