Illustrating, Quantifying, and Correcting for Bias in Post-hoc Analysis of Gene-Based Rare Variant Tests of Association
نویسندگان
چکیده
منابع مشابه
Illustrating, Quantifying, and Correcting for Bias in Post-hoc Analysis of Gene-Based Rare Variant Tests of Association
To date, gene-based rare variant testing approaches have focused on aggregating information across sets of variants to maximize statistical power in identifying genes showing significant association with diseases. Beyond identifying genes that are associated with diseases, the identification of causal variant(s) in those genes and estimation of their effect is crucial for planning replication s...
متن کاملEvaluating basic approaches to post-hoc analysis for commonly used, gene-based rare variant tests of association
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2017
ISSN: 1664-8021
DOI: 10.3389/fgene.2017.00117