IL-4 receptor α polymorphisms are predictors of a pharmacogenetic response to a novel IL-4/IL-13 antagonist
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چکیده
منابع مشابه
Identification and Characterization of a Novel IL-4 Receptor α Chain (IL-4Rα) Antagonist to Inhibit IL-4 Signalling.
BACKGROUND/AIMS In recent times, allergy has become a financial, physical and psychological burden to the society as a whole. In allergic cascades, cytokine IL-4 binds to IL-4 receptor (IL-4R), consequently producing allergen-specific IgE antibodies by B cells. In addition, among other functions, IL-4 is also responsible for B and T cell proliferation and differentiation. Hence, characterizatio...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2010
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2010.08.001