منابع مشابه
Linking Inflammation to Bacteria and Cancer
e live with trillions of microbes in our gut, a rich community of bacteria and other microorganisms that metabolize foods and support our health. A new animal study published in Science now suggests that gut inflammation alters this microbial community – our microbiota – fostering the growth of a toxic form of bacteria that may then cause colorectal cancer. The research also linked this toxic b...
متن کاملRoles of IL-22 in Allergic Airway Inflammation
IL-23- and IL-17A-producing CD4(+) T cell (Th17 cell) axis plays a crucial role in the development of chronic inflammatory diseases. In addition, it has been demonstrated that Th17 cells and their cytokines such as IL-17A and IL-17F are involved in the pathogenesis of severe asthma. Recently, IL-22, an IL-10 family cytokine that is produced by Th17 cells, has been shown to be expressed at the s...
متن کاملIL-22 and IL-17: An Overview
Many studies from recent years have shown that cytokines like IL-22, IL-17A, and IL-17F play a major role in both the defense against certain microbes and the development and maintenance of chronic inflammatory diseases. These mediators are often secreted by subpopulations of T-helper cells called Th17 cells and Th22 cells, respectively. This chapter provides an overview about the common and di...
متن کاملPathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
IL-22 has both proinflammatory and tissue-protective properties depending on the context in which it is expressed. However, the factors that influence the functional outcomes of IL-22 expression remain poorly defined. We demonstrate that after administration of a high dose of bleomycin that induces acute tissue damage and airway inflammation and is lethal to wild-type (WT) mice, Th17 cell-deriv...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2013
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd4065