IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells
نویسندگان
چکیده
منابع مشابه
IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells
The canonical pathway for IL-1β production requires TLR-mediated NF-κB-dependent Il1b gene induction, followed by caspase-containing inflammasome-mediated processing of pro-IL-1β. Here we show that IL-21 unexpectedly induces IL-1β production in conventional dendritic cells (cDCs) via a STAT3-dependent but NF-κB-independent pathway. IL-21 does not induce Il1b expression in CD4(+) T cells, with d...
متن کاملIL-1β/CD14 pathway induces IL-17 production: Dendritic cells activated with IL-1β set Th17 cells on fire by CD14-mediated mechanisms.
I n 2005, the description of a new subset of effector CD4 + T cells called Th17 broke the Th1/Th2 paradigm. Since then, Th17 cells and their eponymous cytokine interleukin (IL)-17 have emerged as central players underlying not only inflammatory and autoimmune processes but also host resistance to several infections. A selected group of pro-inflammatory cytokines including IL-1β, IL-6 and IL-23 ...
متن کاملIL-21 induces IL-22 production in CD4+ T-cells
Interleukin (IL)-22 produced by innate lymphoid cells (ILCs) and CD4+ T cells plays an important role in host defence and mucosal homeostasis, thus it is important to investigate the mechanisms that regulate IL-22 production. We investigated the regulation IL-22 production by CD4+ T cells. Here we show that IL-21 triggers IL-22, but not IL-17 production by CD4+ T cells. STAT3, activated by IL-2...
متن کاملInflammasome-Mediated IL-1β Production in Humans with Cystic Fibrosis
BACKGROUND Inflammation and infection are major determinants of disease severity and consequently, the quality of life and outcome for patients with cystic fibrosis (CF). Interleukin-1 beta (IL-1β) is a key inflammatory mediator. Secretion of biologically active IL-1β involves inflammasome-mediated processing. Little is known about the contribution of IL-1β and the inflammasomes in CF inflammat...
متن کاملIL-1β (+3953 C/T) and IL-8 (-251 A/T) Gene Polymorphisms in H. pylori Mediated Gastric Disorders
Background: Previous studies imply that IL-1 and IL-8 gene variations may play a crucial role in the genetic predisposition to different gastric disorders upon H. pylori infection. Objective: The aim of this study was to determine the potential association between the prevalence of certain polymorphic sites and the risk of gastric disorders in Iranian population. Methods: One hundred and forty ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2015
ISSN: 2041-1723
DOI: 10.1038/ncomms8988