IL-2 regulation of soluble IL-2 receptor levels following thermal injury

Biological significance of soluble IL-2 receptor

A NUMBER of receptors for growth factors and differentiation antigens have been found to be secreted or released by cells. Following mononuclear cell (MNC) activation and interleukin-2 receptor (IL-2R) expression, a soluble form of the Alpha;-chain of IL-2R (sIL-2R) is released. The sIL-2R has been shown to be present in the culture supernatants of activated MNCs as well as in normal sera and, ...

LEVELS OF SOLUBLE IL-2 RECEP TORS IN SERA OF IRANIAN PATIENTS WITH BEHCET\'S DISEASE

It has been shown that activated T-cells produce and release both IL-2 and IL- 2 receptors (lL-2R). The rate of IL-2 release is proportional to its cell surface expression and state of cell activation. To clarify the molecular basis of this immunological aberration, we analysed the amount of soluble IL-2R(SIL2-R) by an ELISA technique in 68 patients with Behcet's disease (BD), 28 patient co...

Soluble IL-2 Receptor: A Biomarker for Assessing Myositis Activity

OBJECTIVE To evaluate the clinical significance of serum soluble IL-2R (sIL-2R) in inflammatory myopathies. METHODS Serum sIL-2R and CK levels were determined in 27 patients with IM during periods of disease exacerbation and inactive disease and were compared to 20 healthy controls and 23 controls with noninflammatory elevated CK. The performance of sIL-2R and CK tests for assessing disease a...

Regulation Following Costimulation Through Molecular Mechanisms of IL-2 Gene

Increased soluble IL-2 receptor levels in serum from a patient with painless thyroiditis

CONTEXT Serum concentration of soluble interleukin-2 receptor (sIL-2R) has been established as a reliable marker of T-lymphocyte activation. However, there have been no reports describing the relationship between serum sIL-2R and painless thyroiditis. OBJECTIVE We report a case of a 76-yr-old female with a significant and temporary increase of sIL-2R concomitant with painless thyroiditis. C...