منابع مشابه
The TLR and IL-1 signalling network at a glance.
Toll-like receptors (TLRs) and the receptors for interleukin (IL)-1, IL-18 and IL-33 are required for defence against microbial pathogens but, if hyper-activated or not switched off efficiently, can cause tissue damage and inflammatory and autoimmune diseases. Understanding how the checks and balances in the system are integrated to fight infection without the network operating out of control w...
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LOX-1 is a class E scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved in endothelial dysfunctions, monocyte adhesion, the proliferation, migration, and apoptosis of smooth muscle cells, foam cell formation, platelet activation, as well as plaque instability; all of these events are critical in the pathogenesis of atherosclerosis. These LOX-1-dependent bio...
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Cardiovascular diseases, including coronary artery disease (CAD), ischemic gangrene, abdominal aortic aneurysms, and many cases of heart failure and stroke currently account for the most number of deaths in the Western world (Hansson et al., 2006). The root cause of these diseases is atherosclerosis, which is widely accepted these days to be a chronic inflammatory disease in addition to the mor...
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Atherosclerosis is a chronic inflammatory disease of the arterial wall driven by innate and adaptive immunity. Atherosclerotic lesions contain a variety of cells including smooth muscle cells, macrophages, and T lymphocytes, as well as other inflammatory cells, such as mast cells and NKT cells. This collection of cells promotes the development of atherosclerosis through the production of inflam...
متن کاملExpression of IGF-1, IL-27 and IL-35 Receptors in Adjuvant Induced Rheumatoid Arthritis Model
Background: IGF-1 and certain other cytokines have been shown to exert inflammatory/anti-inflammatory roles in chronic joint diseases. Objective: To assess the effect of IGF-1, IL-27 and IL-35, their interaction and their receptor expression in a rheumatoid arthritis model. Methods: Freund’s adjuvant-induced chronic joint inflammation was operated on 160 male rats. Animals were divided into his...
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ژورنال
عنوان ژورنال: Nature Reviews Cardiology
سال: 2019
ISSN: 1759-5002,1759-5010
DOI: 10.1038/s41569-019-0172-7