IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis
نویسندگان
چکیده
منابع مشابه
Inflammasome-Mediated IL-1β Production in Humans with Cystic Fibrosis
BACKGROUND Inflammation and infection are major determinants of disease severity and consequently, the quality of life and outcome for patients with cystic fibrosis (CF). Interleukin-1 beta (IL-1β) is a key inflammatory mediator. Secretion of biologically active IL-1β involves inflammasome-mediated processing. Little is known about the contribution of IL-1β and the inflammasomes in CF inflammat...
متن کاملCytokine profile of chronic sinusitis in patients with cystic fibrosis.
BACKGROUND The inflammatory-cell and cytokine profiles of chronic sinusitis (CS) are well documented in the literature. In contrast, little is known about the pathogenesis of this condition in patients with cystic fibrosis (CF). OBJECTIVE To determine whether patients with CF have inflammatory-cell and cytokine profiles that differ from other patients with CS. METHODS Patients with CF (n = ...
متن کاملPlasma Cytokine Profile in Tropical Endomyocardial Fibrosis: Predominance of TNF-a, IL-4 and IL-10
BACKGROUND The participation of immune/inflammatory mechanisms in the pathogenesis of tropical endomyocardial fibrosis (EMF) has been suggested by the finding of early blood and myocardial eosinophilia. However, the inflammatory activation status of late-stage EMF patients is still unknown. METHODOLOGY/PRINCIPAL FINDINGS We evaluated pro- and anti-inflammatory cytokine levels in plasma sample...
متن کاملRole of IL-1β in Experimental Cystic Fibrosis upon P. aeruginosa Infection
Cystic fibrosis is associated with increased inflammatory responses to pathogen challenge. Here we revisited the role of IL-1β in lung pathology using the experimental F508del-CFTR murine model on C57BL/6 genetic background (Cftr(tm1eur) or d/d), on double deficient for d/d and type 1 interleukin-1 receptor (d/d X IL-1R1-/-), and antibody neutralization. At steady state, young adult d/d mice di...
متن کاملCatabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile
Low back pain is a common and debilitating disorder. Current evidence implicates intervertebral disc (IVD) degeneration and herniation as major causes, although the pathogenesis is poorly understood. While several cytokines have been implicated in the process of IVD degeneration and herniation, investigations have predominately focused on Interleukin 1 (IL-1) and tumor necrosis factor alpha (TN...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2019
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci125669