IKZF1 alterations predict poor prognosis in adult and pediatric T-ALL
نویسندگان
چکیده
منابع مشابه
HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis.
The most frequent oncogenic activation events characterized in childhood T acute lymphoblastic leukemia (T-ALL) result in the transcriptional activation of genes coding for transcription factors. The main genes are TAL1/SCL, a member of the basic region helix-loop-helix gene family, and HOX11L2, a member of the homeobox-containing protein family. To gain insight into the pathogenesis of this ty...
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ژورنال
عنوان ژورنال: Blood
سال: 2021
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.2020007959