<i>In Vivo</i> T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design

T cells play an important role in immunity and repair are implicated diseases, including blood cancers, viral infections, inflammation, making them attractive targets for the treatment prevention of diseases. Over recent years, advent nanomedicine has shown increase studies that use nanoparticles as carriers to deliver therapeutic cargo ex vivo applications. Nanoparticle-based delivery several advantages, ability load protect a variety drugs, control drug release, improve pharmacokinetics biodistribution, site- or cell-specific targeting. However, remains major technological challenge, which is primarily due nonphagocytic nature cells. In this review, we discuss physiological barriers effective cell targeting describe different approaches used cargo-loaded disease such lymphoma human immunodeficiency virus (HIV). particular, engineering strategies aim nanoparticle internalization by cells, ligand-based targeting, will be highlighted. These expected inspire development nanomaterials can target manipulate function cell-related