IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche
نویسندگان
چکیده
منابع مشابه
Niche-mediated control of human embryonic stem cell self-renewal and differentiation.
Complexity in the spatial organization of human embryonic stem cell (hESC) cultures creates heterogeneous microenvironments (niches) that influence hESC fate. This study demonstrates that the rate and trajectory of hESC differentiation can be controlled by engineering hESC niche properties. Niche size and composition regulate the balance between differentiation-inducing and -inhibiting factors....
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2020
ISSN: 2041-1723
DOI: 10.1038/s41467-020-14629-x