IGF-I, IGFBP1 and IGFBP3 Changes in Cancer Children Treated with Megestrol Acetate. 10
نویسندگان
چکیده
منابع مشابه
A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among Caucasians.
The insulin-like growth factor (IGF) pathway has been implicated in prostate development and carcinogenesis. We conducted a comprehensive analysis, utilizing a resequencing and tagging single-nucleotide polymorphism (SNP) approach, between common genetic variation in the IGF1, IGF binding protein (BP) 1, and IGFBP3 genes with IGF-I and IGFBP-3 blood levels, and prostate cancer (PCa) risk, among...
متن کاملThe effects of tonsillectomy and adenoidectomy on serum IGF-I and IGFBP3 levels in children.
OBJECTIVE Obstructive adenoid and tonsillar hyperplasia may present with retardation of growth. Interruption of growth hormone-insulin-like growth factor I axis resulting from abnormal nocturnal growth hormone secretion is among the postulated causes. Growth hormone (GH) mediates its anabolic effects on tissues through insulin-like growth factor I (IGF-I). Most of the circulating IGF-I is bound...
متن کاملPhase I trial of paclitaxel plus megestrol acetate in patients with paclitaxel-refractory ovarian cancer.
Increased expression of P-glycoprotein has been proposed as one important mechanism for inherent or acquired drug resistance of malignant disease to cytotoxic chemotherapy. In experimental systems, hormonal agents, including megestrol acetate (MA), have been shown to be capable of reversing P-glycoprotein-mediated multidrug resistance to natural products, including paclitaxel. Because paclitaxe...
متن کاملCommon genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk.
Insulin-like growth factor (IGF) 1 and its binding proteins foster cellular proliferation and inhibit apoptosis. In vitro studies show that IGF1 increases ovarian cell growth and invasive potential, suggesting a role for the IGF1 pathway in ovarian cancer etiology. We evaluated genetic variation in the IGF1, IGFBP1 and IGFBP3 genes in relation to ovarian cancer risk by genotyping 29 haplotype-t...
متن کاملHistological Changes in the Liver and Biochemical Parameters of Chickens Treated with Lead Acetate II
Background: Lead is one of the heavy metals that is persists in the environment and has destructive effects on various human tissues. We investigated the effects of lead on the histological features of liver and its enzymatic functions. Methods: Forty chickens were purchased and randomly divided into four groups. In addition to the normal feed, each group received different doses of lead aceta...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1996
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199609000-00033