IFN-λ4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling

Negative regulation of IFN- signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells

The development and cooperation of distinct subsets of antigenpresenting cells, particularly dendritic cells (DCs), may be critical for maintaining homeostatic immune responses. Recently, much attention has been focused on IFN, the cytokines induced en masse by virus infection or the activation of Toll-like receptors, in the context of DC activation. Here, we show that mice deficient in IFN reg...

IFN- Secreted during Infection Is Necessary but Not Sufficient for Negative Feedback Regulation of IFN- Signaling by Mycobacterium tuberculosis

Negative Feedback Regulation of IFN-; Pathway by IFN Regulatory Factor 2 in Esophageal Cancers

IFN-; is an antitumor cytokine that inhibits cell proliferation and induces apoptosis after engagement with the IFN-; receptors (IFNGR) expressed on target cells, whereas IFN regulatory factor 2 (IRF-2) is able to block the effects of IFN-; by repressing transcription of IFN-;–induced genes. Thus far, few studies have explored the influences of IFN-; on human esophageal cancer cells. In the pre...

Induction of antiviral factors by IFN-α 2a is time and dose dependent

Background and Aims: Interferon alpha is an effective cytokine in viral infections, where it has various roles in immune function. The use of this antiviral agent in the treatment of viral infections and even cancers is common, although, the beneficial effects of this antiviral agent in high doses can be associated with side effects that limit its use. In this project, we tried to investigate t...

Comparative Functional Analysis of 12 Mammalian IFN-λ4 Orthologs

IFN-λ4 is a novel type-III interferon with strong clinical significance in humans. Only a subset of individuals--up to 10% of Asians, 50% of Europeans, and 90% of Africans--carry the ΔG allele of a genetic variant rs368234815-TT/ΔG and are genetically able to produce IFN-λ4 protein. Carriers of the ΔG allele have impaired ability to clear infection with hepatitis C virus (HCV). IFN-λ4 is also p...