IFA Proof of Principle Experiments

Stellarator Proof of Principle Program

Proof-of-principle experiments for react--wind--sinter manufacturing of Bi2Sr2CaCu2Ox magnets

The manufacturing of long lengths of Bi2Sr2CaCu2Ox (Bi2212) wire has led to the development of high-field magnets at low temperature. Both react-and-wind and wind-and-react manufacturing of magnets, however, have significant drawbacks that limit the performance of the conductor in magnet form. In this letter, an alternative approach to magnet manufacturing, react–wind–sinter, is proposed to avo...

Transmitochondrial mice: proof of principle and promises.

S ince the initial identification of pathogenic mutations in 1988, more than 100 point mutations and numerous largescale deletions of human mtDNA have been associated with a wide range of clinical phenotypes (1). The development, by King and Attardi, of cells in culture called cybrids (cytoplasmic hybrids) provided an in vitro method to study mtDNA mutations against a uniform nuclear (nDNA) bac...

Antiangiogenesis in recurrent glioblastoma: proof of principle

Glioblastoma multiforme, a neoplasm with variable histological and biological features, is characterized by diverse imaging features, including highly heterogeneous enhancement. This reflects variable disruption of the blood brain barrier and inherent differences in the vascularity of the tumor. Experience in treating malignant glioma with antiangiogenic drugs is growing, and the most commonly ...

Graft-versus-myeloma effect: proof of principle.

The presence of a graft-versus-tumor effect has been well established in leukemia but not in multiple myeloma. A 40-year-old patient with myeloma refractory to standard chemotherapy and autologous transplantation received a matched unrelated T-cell-depleted transplant after conditioning with fractionated total-body irradiation, thiotepa, and cyclophosphamide. This procedure resulted in a transi...