Identifying clinicopathological risk factors for regional lymph node metastasis in Chinese patients with T1 breast cancer: a population-based study

Objectives To analyze clinicopathological risk factors and regular pattern of regional lymph node metastasis (LNM) in Chinese patients with T1 breast cancer the effect on overall survival (OS) disease-free (DFS). Materials methods Between 1999 2020, meeting inclusion criteria unilateral, no distant metastatic site, invasive ductal carcinoma were reviewed. Clinical pathology characteristics retrieved from medical records. Survival analysis was performed using Kaplan−Meier an adjusted Cox proportional hazards model. Results We enrolled 11,407 eligible as a discovery cohort to explore for LNM 3484 stage T1N0 identify those OS DFS. Compared N- status, N+ status had younger age, larger tumor size, higher Ki67 level, grade, HR+ HER2+ percentages, luminal B HER2-positive subtype percentages. Logistic regression indicated that age protective factor size/higher grade/HR+ LNM. limited (N1) patients, extensive (N2/3) sizes, levels, grades, HR- lower A grade/HER2+ grade predictor both DFS; HR but not Multivariate model demonstrated level be predictors HER2 DFS patients. Conclusion In there several differences between Besides, plays dual role without LNM, are OS,