Identifying cancer biomarkers by mass spectrometry-based glycomics
نویسندگان
چکیده
منابع مشابه
Glycomics Using Mass Spectrometry
Mass spectrometry (MS), which has advanced rapidly in recent years, is expected to become the tool of choice for high-throughput analysis of relationships between structures and functions of glycans. The structural analysis of glycans using MS employs a number of methods for pretreatment, derivatization, and interpretation. However, since none of these are universally applicable, researchers ha...
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Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. An increased molecular understanding of the CRC pathology is warranted to gain insights into the underlying molecular and cellular mechanisms of the disease. Altered protein glycosylation patterns are associated with most diseases including malignant transformation. Recent advances in mass spectrometry and bioinformatics ha...
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In recent years, there has been an increased interest in using protein mass spectroscopy to identify molecular markers that discriminate diseased from healthy individuals. Existing methods are tailored towards classifying observations into nominal categories. Sometimes, however, the outcome of interest may be measured on an ordered scale. Ignoring this natural ordering results in some loss of i...
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measured components should be lower to obtain an acceptable CV for calculated LDL and thus reach the Six Sigma goal. Otherwise, we must measure the serum LDL concentration by chemical methods. In conclusion, when a QA process is implemented in the clinical laboratory, application of that process only to measured tests is inadequate. Because of their higher CVs, results of calculated tests have ...
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ژورنال
عنوان ژورنال: ELECTROPHORESIS
سال: 2012
ISSN: 0173-0835
DOI: 10.1002/elps.201100715