Identification of two novel alternatively spliced Neuropilin-1 isoforms
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چکیده
منابع مشابه
Tissue-specific distributions of alternatively spliced human PECAM-1 isoforms.
Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a cell adhesion molecule that is highly expressed on the surface of endothelial cells and some hematopoietic cells. Its cytoplasmic domain is encoded by multiple exons, which undergo alternative splicing. Here, we demonstrate that the human PECAM-1 cytoplasmic domain undergoes alternative splicing, generating six different isoforms. RT-...
متن کاملTissue specific expression of alternatively spliced murine PECAM-1 isoforms.
PECAM-1 (CD31) is a cell adhesion molecule that is highly expressed at the sites of endothelial cell-cell contact and at lower levels on the surface of platelets and leukocytes. It is a member of the immunoglobulin gene superfamily and undergoes alternative splicing to generate several isoforms that differ only in their cytoplasmic domains. The tissue distribution of the expression of different...
متن کاملEASI—enrichment of alternatively spliced isoforms
Alternative splicing produces more than one protein from the majority of genes and the rarer forms can have dominant functions. Instability of alternative transcripts can also hinder the study of regulation of gene expression by alternative splicing. To investigate the true extent of alternative splicing we have developed a simple method of enriching alternatively spliced isoforms (EASI) from P...
متن کاملIdentification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina.
PURPOSE Identification of transcription factors that regulate the transcription of the vascular endothelial growth factor (VEGF) gene may facilitate understanding of the etiology and progression of ocular neovascular diseases. The purpose of this study was to determine whether transcriptional enhancer factor 1-related (RTEF-1) was present within ocular vascular endothelial cells and whether it ...
متن کاملStructures of alternatively spliced isoforms of human ketohexokinase
A molecular understanding of the unique aspects of dietary fructose metabolism may be the key to understanding and controlling the current epidemic of fructose-related obesity, diabetes and related adverse metabolic states in Western populations. Fructose catabolism is initiated by its phosphorylation to fructose 1-phosphate, which is performed by ketohexokinase (KHK). Here, the crystal structu...
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ژورنال
عنوان ژورنال: Genomics
سال: 2004
ISSN: 0888-7543
DOI: 10.1016/j.ygeno.2004.02.001