Identification of the Absorbed Components of Raw Fuzi (Lateral Root of Aconitum carmichaelii Debx.) in a Rat Adjuvant Arthritis Model

The aim of the present study was to identify absorbed components raw fuzi in a rat adjuvant arthritis model and evaluate therapeutic effects three alkaloids fuzi’s components, aconitine, hypaconitine mesaconitine. established by complete Freund’s injection Wistar rats. Then animal’s body weight, condition fur, hind paw volume immunological parameters, nitric oxide tumor necrosis factor-alpha, were assessed as markers inflammation arthritis. Serum samples from rats treated with oral extracts analyzed ultra performance liquid chromatography-mass spectrometric 12 prototypes identified. Aconitine mesaconitine could substantially reduce serum levels factor-alpha model, while did not show obvious effects. method for identification simple sensitive. Among alkaloids, aconitine might be major compounds diester-diterpenoid treatment rheumatoid current connected pharmacochemistry pharmacological experiment discovered effective substance fuzi, which provide plausible evidence its using, candidate