Identification of proteins and cellular pathways targeted by 2-nitroimidazole hypoxic cytotoxins

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Hypoxic cells in tissue pose many medical problems, and there is a need for more accurate measurements of tissue hypoxia. However, measurement of the pO2 and the extent of hypoxia within normal and tumor tissue have proven difficult. One of the most sensitive of the currently available methodologies involves the oxygen-dependent metabolic activation of nitroheterocyclic drugs, leading to adduct...

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Detection of Hypoxic Cells by Monoclonal Antibody Recognizing 2-Nitroimidazole Adducts I

Hypoxic cells in tissue pose many medical problems, and there is a need for more accurate measurements of tissue hypoxia. However, measurement of the pO2 and the extent of hypoxia within normal and tumor tissue have proven difficult. One of the most sensitive of the currently available methodologies involves the oxygen-dependent metabolic activation of nitroheterocyclic drugs, leading to adduct...

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Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts.

Hypoxic cells in tissue pose many medical problems, and there is a need for more accurate measurements of tissue hypoxia. However, measurement of the pO2 and the extent of hypoxia within normal and tumor tissue have proven difficult. One of the most sensitive of the currently available methodologies involves the oxygen-dependent metabolic activation of nitroheterocyclic drugs, leading to adduct...

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ژورنال

عنوان ژورنال: Redox Biology

سال: 2021

ISSN: 2213-2317

DOI: 10.1016/j.redox.2021.101905