Identification of potential drugs against SARS-CoV-2 non-structural protein 1 (nsp1)
نویسندگان
چکیده
منابع مشابه
Unique SARS-CoV protein nsp1: bioinformatics, biochemistry and potential effects on virulence.
Viruses have evolved a myriad of strategies for promoting viral replication, survival and spread. Sequence analysis of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) genome predicts several proteins that are unique to SARS-CoV. The search to understand the high virulence of SARS-CoV compared with related coronaviruses, which cause lesser respiratory illnesses, has recently focused...
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Three peptides, D1 (amino acid residues 175-201), D2 (a.a. 434-467), and TM (a.a. 1128-1159), corresponding to the spike protein (S) of severe acute respiratory syndrome corona virus (SARS CoV) were synthesized and their immunological functions were investigated in three different animals models (mice, guinea pigs, and rabbits). The peptides mixture formulated either with Freund's adjuvant or s...
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An epidemic of Severe Acute Respiratory Syndrome (SARS) led to the identification of an associated coronavirus, SARS-CoV. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling. Thus, nsp1 is a promising target for drugs, as inhibition of ...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Structure and Dynamics
سال: 2020
ISSN: 0739-1102,1538-0254
DOI: 10.1080/07391102.2020.1792992