Identification of novel nucleus pulposus markers
نویسندگان
چکیده
منابع مشابه
Identification of novel nucleus pulposus markers
Mesenchymal stem-cell based therapies have been proposed as novel treatments for intervertebral disc degeneration, a prevalent and disabling condition associated with back pain. The development of these treatment strategies, however, has been hindered by the incomplete understanding of the human nucleus pulposus phenotype and by an inaccurate interpretation and translation of animal to human re...
متن کاملNovel Hydrogel for the Replacement of the Nucleus Pulposus
INTRODUCTION Back pain induced by the degeneration of the hydrogel core of the intervertebral disc, the nucleus pulposus (NP) surrounded by the annulus fibrosus (AF), is currently a major public health issue. Different treating approaches exist such as vertebral fusion and total disc replacement with for example a SB Charité Prosthesis. However, recent trends in surgery are shifting towards pre...
متن کاملNucleus pulposus explant culture model.
Many of the therapeutic interventions for intervertebral disc degeneration attempt to repopulate the nucleus pulposus (NP) tissue; however, NP cells are heterogeneous and not well characterized. To address this, we have investigated the morphology, extracellular gene and protein expression, and apoptosis changes in NP explants cultured in vitro with or without chondrogenic reagents for differen...
متن کاملDamping properties of the nucleus pulposus.
BACKGROUND The nucleus pulposus is extremely deformable and it is not uncommon to observe strain amplitudes as large as 12.5% in physiological loading conditions. It has been shown that the nucleus pulposus contributes to the damping properties of the intervertebral disc. The quantification of the damping properties of the nucleus pulposus under physiological large deformations is then a key as...
متن کاملThe Comparative Cytomorphology of Nucleus Pulposus Cells
INTRODUCTION The cells of the embryonic notochord play an important role in formation of the spinal column, including the intervertebral discs (IVDs) (1). These cells become trapped inside the annulus fibrosus and reside within the nucleus pulposus at birth, but are generally lost during aging and replaced by small chondrocyte-like cells. The age at which the notochordal cells are lost varies s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bone & Joint Research
سال: 2013
ISSN: 2046-3758
DOI: 10.1302/2046-3758.28.2000184