Identification of Nogo-66 Receptor (NgR) and Homologous Genes in Fish
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چکیده
منابع مشابه
Identification of Nogo-66 receptor (NgR) and homologous genes in fish.
The Nogo-66 receptor NgR has been implicated in the mediation of inhibitory effects of central nervous system (CNS) myelin on axon growth in the adult mammalian CNS. NgR binds to several myelin-associated ligands (Nogo-66, myelin associated glycoprotein, and oligodendrocyte-myelin glycoprotein), which, among other inhibitory proteins, impair axonal regeneration in the CNS of adult mammals. In c...
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The central nervous system myelin components oligodendrocyte-myelin glycoprotein, myelin-associated glycoprotein and the Nogo-66 domain of Nogo-A inhibit neurite outgrowth by binding the neuronal glycosyl-phosphatidylinositol-anchored Nogo-66 receptor (NgR) that transduces the inhibitory signal to the cell interior via a transmembrane co-receptor, p75NTR. Here, we demonstrate that human NgR exp...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2004
ISSN: 1537-1719,0737-4038
DOI: 10.1093/molbev/msg241