Identification of Mycobacterium phlei TMC 1523 and Mycobacterium smegmatis SN40 as Members of Mycobacterium smegmatis and Mycobacterium fortuitum, Respectively: Selective Inhibition by Trimethoprim
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MICROBIAL TRANSFORMATION OF CHOLESTEROL BY MYCOBACTERIUM SMEGMATIS
Mycobacterium smegmatis PTCC 1307 (CIP 73.26) was used as a microbial agent to produce androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione, two useful precursors in the synthesis of steroid drugs. The side chain of cholesterol, as the substrate, was selectively cleaved in the presence of five enzyme inhibitors. An intermediate structure with intact side chain, cholest-4-ene-3-one, ...
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With the techniques found suitable for the growth of tubercle bacilli in HeLa cells (Shepard, 1955, 1957a) little extracellular bacterial growth occurs when virulent strains are used. When rapidly growing mycobacteria (Gordonand Smith, 1953, 1955) are introduced into the tissue cultures in the same concentration, bacterial growth in the extracellular tissue culture fluid is rapid and soon resul...
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Rapidly growing mycobacteria of clinical significance were identified by mycolic acids detected with high-performance liquid chromatography. Mycolic acids from whole cells were extracted, derivatized, and detected by a modified high-performance liquid chromatography procedure in less than 3 h. Use of an internal standard allowed differentiation of Mycobacterium chelonae and Mycobacterium fortui...
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The modified fluorescence method was used to determine the accumulation of norfloxacin by Mycobacterium aurum A+ and Mycobacterium smegmatis mc(2)155. By using an exogenous norfloxacin concentration of 10 microg/ml, a steady-state concentration (SSC) of 160 to 180 ng of norfloxacin/mg of cells was obtained for M. aurum, and an SSC of 120 to 140 ng of norfloxacin/mg of cells obtained for M. smeg...
متن کاملmicrobial transformation of cholesterol by mycobacterium smegmatis
mycobacterium smegmatis ptcc 1307 (cip 73.26) was used as a microbial agent to produce androsta-1,4-diene-3,17-dione (add) and androst-4-ene-3,17-dione, two useful precursors in the synthesis of steroid drugs. the side chain of cholesterol, as the substrate, was selectively cleaved in the presence of five enzyme inhibitors. an intermediate structure with intact side chain, cholest-4-ene-3-one, ...
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ژورنال
عنوان ژورنال: International Journal of Systematic Bacteriology
سال: 1978
ISSN: 0020-7713,1465-2102
DOI: 10.1099/00207713-28-4-602